Filtration Solutions from R&D to Production at Spectrum Labs

Edition: Europe

Spectrum Labs, the leader in filtration and laboratory dialysis.

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Hollow Fiber Filters

Perfusion Assemblies and Systems at Spectrum Labs

TangenX Tangential Flow Filtration (TFF)

Guide to Process Scalability for Spectrum Hollow Fiber Modules

Due to the consistent flow dynamics between hollow fiber membranes, Spectrum filters lend themselves to direct volume and surface area scalability by increasing the number of fibers while maintaining the same fiber flow path length. This allows you to easily transition from R & D (MicroKros®, MidiKros®, MiniKros® Sampler) to Process Development (MiniKros) and on to Production (KrosFlo®). Module total length (TL) and fiber effective length (EL) are shown below.

MicroKros Modules

for process volumes from 1 ml to 100 ml

Connections		Scale Length	EL (cm)	TL (cm)	Surface Area (cm²)
Inlet/Outlet	Side Port
MLL	FLL	1xFL	20	23	13 - 20

MidiKros Modules

for process volumes from 100 ml to 3 L

Connections		Scale Length	EL (cm)	TL (cm)	Surface Area (cm²)
Inlet/Outlet	Side Port
FLL	FLL	1xFL	20	25	75 - 115
		2xFL	41,5	45	155 - 235
		3xFL	65	69	245 - 370

MidiKros TC Modules

for process volumes from 100 ml to 3 L

Connections		Scale Length	EL (cm)	TL (cm)	Surface Area (cm²)
Inlet/Outlet	Side Port
1/2" TC	FLL	1xFL	20	25	75 - 115
		2xFL	41,5	45	155 - 235
		3xFL	65	69	245 - 370

MiniKros Sampler Modules

for process volumes from 3 L to 15 L

Connections		Scale Length	EL (cm)	TL (cm)	Surface Area (cm²)
Inlet/Outlet	Side Port
3/4" TC	3/4" TC	1xFL	20	25	490 - 790
		2xFL	41,5	47	1000 - 1600
		3xFL	65	70	1600 - 2600

MiniKros Modules

for process volumes from 5 L to 50 L

Connections		Scale Length	EL (cm)	TL (cm)	Surface Area (m²)
Inlet/Outlet	Side Port
1,5" TC	3/4" TC	1xFL	20	25	0,16 - 0,26
		2xFL	41,5	46	0,33 - 0,54
		3xFL	65	70	0,51 - 0,85

KrosFlo Modules

for process volumes from 10 L to 100 L

Connections		Scale Length	EL (cm)	TL (cm)	Surface Area (m²)
Inlet/Outlet	Side Port
3" TC	1,5" TC	1xFL	20	23	0,9 - 1,25
		2xFL	41,5	46	1,65 - 2,6
		3xFL	65	69	2,55 - 4,1

KrosFlo Max Modules

for process volumes from 100 L to 1000+ L

Connections		Scale Length	EL (cm)	TL (cm)	Surface Area (m²)
Inlet/Outlet	Side Port
2" TC	1,5" TC	R65	49,9	73,5	6,2 - 8,2
		3xFL	67,9	91,5	8,5 - 11,2
		R85	107,5	131,1	13,4 - 17,7

hi dave

Filter Module Scalability