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MiniKros® Sampler Plus Filter Modules

Disposable Hollow Fiber Tangential Flow Modules for R & D Scale Volumes

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The MiniKros Sampler Plus consists of Spectrum's high quality hollow fiber membranes encased in a symmetrical polysulfone housing with either 3/8" HB, 3/4" TC or 1-1/2" TC inlet/outlet circulation ports and two 3/8" filtrate side-ports. There is one housing size that offers two surface areas for each fiber type polysulfone, PES and mixed cellulose ester) and fiber diameter (1,0 mm and 0,5 mm). The surface areas range from 120 to 615 cm2. The MiniKros Sampler Plus modules are designed to be used with Spectrum's KrosFlo Research IIi System, but are so versatile that they can be used with most R &D scale filtration systems.

SA (cm2)Scale LengthID (mm)TL (cm)EL (cm)


Inlet/Outlet Ports:1-1/2" Sanitary, 3/4" Sanitary, 3/8" Hose Barb
Filtrate Ports:3/8" Hose Barb
Process Volume:50 mL to 3 Liters
Surface Area:120 to 615 cm2

MembraneFiber IDMWCO
Mixed Cellulose Ester (ME)0,6 mm, 1,0 mm0,2 µm, 0,1 µm
Polyethersulfone (PES)0,5 mm, 1,0 mm0,5 µm, 0,2 µm
Polysulfone (PS)0,5 mm0,05 µm, 20 nm (500 kD), 100 kD, 50 kD, 10 kD

1,0 mm100 kD

Advantages of Disposability

  • Easier FDA Validation
  • Saves Money & Time
  • No Cross-Contamination
  • Less Down-Time
  • Low Shear
  • Directly Scalable for Production
  • Easy Retrofit for other HF Modules


  • Cell Concentration, Clarification and Diafiltration
  • Lysate Clarification
  • VLP and Virus Concentration and Diafiltration
  • VLP and Virus Clarification
  • Protein Purification, Concentration and Diafiltration
  • Nucleic Acid Diafiltration and Concentration
  • NanoParticle and Latex Particle Diafiltration and Fractionation
  • In situ Conjugation and Fractionation
  • Bacteria Concentration and Diafiltration
  • Liposome, siRNA Concentration and Diafiltration
  • Inclusion body Clarification and Concentration
  • Bioreactor cell Perfusion and Media Exchange


KrosFlo Research IIi System
for volumes 1ml to 10L
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