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MiniKros® Sampler Filter Modules


Disposable Hollow Fiber Tangential Flow Modules for R & D Scale Volumes

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The MiniKros Sampler module is the ideal device for the efficient filtration of R & D scale volumes of precious samples. Tangential flow filtration is the most efficient alternative for the gentle processing of delicate samples like dissolved biological or cellular suspensions. The Spectrum MiniKros Sampler module consists of high quality hollow fiber membranes encased in a polysulfone housing with circulation inlet and outlet ports and two filtration side ports. The hollow fiber membrane geometry provides consistent filtration performance, direct scalability and high product recovery due to capillary flow dynamics.

KrosFlo Research IIi System


Utilizes a peristaltic pump to recirculate the sample and quickly process R & D scale volumes (50mL-15L) for filtration characterization. The desired product can be purified and concentrated as retentate or clarified and purified as filtrate depending on the size of desired product and the filter pore size or MWCO.
Dimensions:
SA (cm2)Scale
Length
Housing
ID (mm)
TL (cm)EL (cm)
120-6152/3xFL15,8718,512,2
100-4701xFL15,872520
980-22002xFL15,874741,5
1500-34003xFL15,877065

Specifications:

Housing:Polysulfone
Connections:1/4" hose barb inlet/outlet ports
Female Luer Lok filtrate (FLL)
or 3/4" TC inlet ports and 3/4" TC outlet ports
Potting:Polyurethane
Process Volume:50mL-15L

4 MembranesFiber IDMWCO
Modified Polyethersulfone (mPES)0,5 mm3 kD, 5 kD, 10 kD, 30 kD, 50 kD, 70 kD, 100 kD, 300 kD, 500 kD (20 nm), 0,2 µm
1,0 mm3 kD, 10 kD, 30 kD, 50 kD, 70 kD, 100 kD, 300 kD, 500 kD (20 nm)
Mixed Cellulose Ester (ME)0,6 mm0,1 µm, 0,2 µm
1,0 mm0,2 µm
Polyethersulfone (PES)0,5 mm0,2 µm
1,0 mm0,2 µm, 0,5 µm
Polysulfone (PS)0,5 mm10 kD, 50 kD, 500 kD (20 nm), 0,05 µm (50 nm)

Advantages of Disposability

  • Easier FDA Validation
  • Saves Money & Time
  • No Cross-Contamination
  • Less Down-Time
  • Low Shear
  • Directly Scalable for Production
  • Easy Retrofit for other HF Modules

Applications:

  • Cell Concentration, Clarification and Diafiltration
  • Lysate Clarification
  • VLP and Virus Concentration and Diafiltration
  • VLP and Virus Clarification
  • Protein Purification, Concentration and Diafiltration
  • Nucleic Acid Diafiltration and Concentration
  • NanoParticle and Latex Particle Diafiltration and Fractionation
  • In situ Conjugation and Fractionation
  • Bacteria Concentration and Diafiltration
  • Liposome, siRNA Concentration and Diafiltration
  • Inclusion body Clarification and Concentration
  • Bioreactor cell Perfusion and Media Exchange

Filtration Resources:







HF Filter Modules Standard Product Number Key



RELATED PRODUCTS:

KrosFlo Research IIi System
for volumes 1ml to 10L
Learn More >

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