Hollow Fiber Modules for Small Volume Filtration and Characterization
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Designed for gentle cross flow filtration of small volumes ranging from
2 - 50 ml, disposable MicroKros Hollow Fiber Modules are the first efficient
and practical tangential flow filtration device for R&D volumes in
the laboratory setting. While MicroKros modules are typically operated
by a peristaltic pump, these devices also offer the unique advantage
of manual operation for quick and convenient separations for small
volumes. Concentration utilizes two retentate syringes connected to
the luer inlet/outlet ports to pass the sample back and forth through
the membrane lumen while a third syringe collects the filtrate by way
of one of the side-ports. In diafiltration, a fourth syringe can be used
to either supply more sample for concentration or buffer for diafiltration
via the luer T connector.
While MicroKros modules can be operated using a small capacity peristaltic pump, these devices also offer
the unique advantage of hand operation for quick and convenient separations of very small volumes. Hand
operation utilizes two retentate syringes connected to the luer inlet/outlet ports (by way of Luer T's) to pass the
sample back and forth through the membrane lumen. A third syringe is connected to one of the female luer side
ports to receive the filtrate as the retentate volume diminishes. A fourth syringe, connected to one of the inlet Luer
T's can be used to either supply more sample for concentration or buffer for diafiltration.
Concentration
Diafiltration
Advantages of Disposability
Easier FDA Validation
Saves Money & Time
No Cross-Contamination
Less Down-Time
Low Shear
Directly Scalable for Production
Easy Retrofit for other HF Modules
Applications:
Cell Concentration, Clarification and Diafiltration
Lysate Clarification
VLP and Virus Concentration and Diafiltration
VLP and Virus Clarification
Protein Purification, Concentration and Diafiltration
Nucleic Acid Diafiltration and Concentration
NanoParticle and Latex Particle Diafiltration and Fractionation
In situ Conjugation and Fractionation
Bacteria Concentration and Diafiltration
Liposome, siRNA Concentration and Diafiltration
Inclusion body Clarification and Concentration
Bioreactor cell Perfusion and Media Exchange
Filtration Resources:
RELATED PRODUCT:
KrosFlo Research IIi System
for volumes 2 - 60 ml Learn More >
