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KrosFlo® Max Modules


Production Scale Hollow Fiber Modules for Processing 1.000 to 50.000 Liters!

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Spectrum introduces the KrosFlo MAX & CellFlo® MAX, the largest hollow fiber filter modules available for the bioprocessing & pharmaceutical industries. These production modules directly scale up from KrosFlo Plus & CellFlo Plus to provide surface areas ranging from 6,2 to 17,7 m2. KrosFlo MAX & CellFlo MAX modules can be operated with the KrosFlo Pharma Production System or a production skid designed by Spectrum to combine and MAX-imize the advantages of gentle hollow fiber flow dynamics, the efficiency of tangential flow filtration and the time & cost savings of disposability. MAX-imize your process filtration!

GENERAL DESCRIPTION


Disposable KrosFlo MAX are available in three convenient sizes. The "300" size provides a direct scale-up of the process volume, flow rate & permeate rate from Spectrum's KrosFlo Plus "3X" size. The "600" and "800" sizes are easy retrofits for commercially available re-usable modules. All three sizes can be connected to any process loop via 2" sanitary retentate ports and 1-1/2" sanitary filtrate ports. Non-irradiated modules can be sterilized once prior to use by autoclaving, irradiation or ETO.

QUALITY ASSURANCE


Spectrum modules are manufactured under cGMP in an ISO class 20 E (US Fed. Class 10.000) cleanroom and are 100% integrity tested and 100% lot traceable. All material of construction meet class VI biocompatibility standards.
Dimensions:
Modules SizeSA (m2)Scale LengthD (cm)TL (cm)L (cm)EL (cm)
xxxx-600-xxx6,2 - 8,2R6511,673,562,849,9
xxxx-300-xxx8,5 - 11,23xFL11,691,581,267,9
xxxx-800-xxx13,4 - 17,7R8511,6131,1120,6107,5

Specifications:

Housing:Clear and Pigmented Polysulfone
Netting:Polypropylene
Flange Nut:Pigmented polysulfone
Inlet/Outlet Reducer:2" sanitary, clear polysulfone
Filtration Side-port:1-1/2" sanitary
Potting:Polyurethane
Process Volume:50 - 5.000 liters
Surface Area:6,2 - 17,7 m2
MembraneFiber IDMWCO
Mixed Cellulose Ester (ME)0,6 mm0,1 µm, 0,2 µm
Polyethersulfone (PES)0,5 mm0,2 µm, 0,5 µm, 500 kD, 100 kD 50 kD, 10 kD
Polysulfone (PS)0,5 mm & 1,0 mm0,05 µm, 20 nm (500 kD), 100 kD, 50 kD, 10 kD

Advantages of Disposability

  • Easier FDA Validation
  • Saves Money & Time
  • No Cross-Contamination
  • Less Down-Time
  • Low Shear
  • Directly Scalable for Production
  • Easy Retrofit for other HF Modules

Applications:

  • Cell Concentration, Clarification and Diafiltration
  • Lysate Clarification
  • VLP and Virus Concentration and Diafiltration
  • VLP and Virus Clarification
  • Protein Purification, Concentration and Diafiltration
  • Nucleic Acid Diafiltration and Concentration
  • NanoParticle and Latex Particle Diafiltration and Fractionation
  • In situ Conjugation and Fractionation
  • Bacteria Concentration and Diafiltration
  • Liposome, siRNA Concentration and Diafiltration
  • Inclusion body Clarification and Concentration
  • Bioreactor cell Perfusion and Media Exchange

Filtration Resources:










RELATED PRODUCTS:

KrosFlo Max Module Wrench
Learn More >

KrosFlo Pilot Plus System
for volumes up to 2.000 L
Learn More >

KrosFlo LDF-37 System
for volumes from 50 to 750+ L
Learn More >

Custom Production System
Learn More >

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