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KrosFlo® Filter Modules


Disposable Hollow Fiber Tangential Flow Modules

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The disposable KrosFlo hollow fiber filter is the ideal device for the quick filtration of production scale volumes resulting in high product yields. Hollow Fiber Tangential Flow is the most efficient filtration alternative for the gentle processing of delicate applications like cellular harvesting and antibody production. It has become the industry standard for processing latex microparticles. The Spectrum KrosFlo module consists of high quality hollow fiber membranes potted in a chemically resistant polysulfone housing for product recirculation through 3-inch sanitary inlet/outlet connections and filtrate collection via 1 1/2 inch sanitary side connections. The hollow fiber membrane geometry and capillary flow dynamics provide consistent filtration performance and direct scalability from process development to production scales.

Dimensions:
SA (m2)Scale LengthID (mm)TL (cm)EL (cm)
0,785-1,601xFL63,502320,0
1,65-3,252xFL63,504641,5
2,55-5,103xFL63,506965,0

Specifications:

Housing:Polysulfone
Connections:3-inch sanitary tri-clover (TC) inlet/outlet ports
1-1/2-inch sanitary tri-clover (TC) side port
Potting:Polyurethane
Process Volume:100L-1000+L
Surface Area:0,785-5,10

MembraneFiber IDMWCO
Modified Polyethersulfone (PES)0,5 mm3 kD, 5kD,10kD,30kD, 50kD, 70kD, 100kD, 500kD
1,0 mm30kD, 50kD, 100kD, 500kD
Mixed Cellulose Ester (ME)0,6 mm0,2 µm, 0,1 µm
Polyethersulfone (PES)0,5 mm0,5 µm, 0,2 µm
Polysulfone (PS)0,5 mm, 1,0 mm0,05 µm, 20 nm (500 kD), 100 kD, 50 kD, 10 kD

Advantages of Disposability

  • Easier FDA Validation
  • Saves Money & Time
  • No Cross-Contamination
  • Less Down-Time
  • Low Shear
  • Directly Scalable for Production
  • Easy Retrofit for other HF Modules

Applications:

  • Cell Concentration, Clarification and Diafiltration
  • Lysate Clarification
  • VLP and Virus Concentration and Diafiltration
  • VLP and Virus Clarification
  • Protein Purification, Concentration and Diafiltration
  • Nucleic Acid Diafiltration and Concentration
  • NanoParticle and Latex Particle Diafiltration and Fractionation
  • In situ Conjugation and Fractionation
  • Bacteria Concentration and Diafiltration
  • Liposome, siRNA Concentration and Diafiltration
  • Inclusion body Clarification and Concentration
  • Bioreactor cell Perfusion and Media Exchange

Filtration Resources:










RELATED PRODUCTS:

KrosFlo Pilot Plus System
for volumes up to 2,000 L
Learn More >

KrosFlo LDF-37 System
for volumes from 50 to 750+ L
Learn More >

Custom Production System
For up to 100,000 L or more
Learn More >

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