KrosFlo® Research IIi Tangential Flow Filtration System
Fully integrated Tangential Flow Filtration System for processing R&D volumes
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The KrosFlo Research IIi Tangential Flow Filtration (TFF) System is the ideal system for small volume, R&D
scale microfiltration and ultrafiltration.
Processing volumes range from 1ml to 10L.
The system consists of the KrosFlo Research IIi
Pump and Pump Head, with an integrated KrosFlo Digital Pressure Monitor,
KF Comm Data Collection Software, Disposable flow-path kit and Fittings kit, all of which have features
that ensure efficient and reproducible Tangential Flow Filtration processing. The Pump Drive used in
conjunction with the KrosFlo Research IIi Pump Head provides flow rates from 0.01 to 2300 mL/min.
The system has both audible and visual low and high pressure alarms for the inlet and permeate and a
high-pressure pump shutoff that helps maintain membrane integrity and achieve high product recovery.
The KrosFlo Research IIi TFF system comes with KF COMM, a software program that automatically downloads
and graphs the run data including inlet, retentate and transmembrane pressures and flow rates, into a
Microsoft® Excel® spreadsheet. The disposable flow-path kit includes pressure transducers,
tubing and fittings, which eliminate the possibility of cross contamination, and allow samples to be concentrated
down to as low as 1 ml. Other standard features include: a digital readout of the recirculation flow rate,
the easy-to-use KrosFlo Research IIi Pump Head, and adjustable holders that attach to the pump drive and secure
the process vessels, Spectrum's Hollow Fiber Filters and the entire flow-path.
The KrosFlo Research IIi TFF System offers many conveniences over traditional cross-flow membrane systems.
The compact fully integrated filtration system and hollow fiber filters provide faster and gentler separation while avoiding membrane fouling and maximizing product recovery.
Used in conjunction with KrosFlo Hollow Fiber membrane filters, the KrosFlo Research IIi TFF System offers the following advantages:
Faster processing times
Superior filtration dynamics
< 1ml TFF hold up volume
Single-Use Filtration Flow path
Lower costs
Direct and easy scale-up from R&D to production volumes
KrosFlo KRIIi Systems Components
The KRIIi has the KrosFlo Research II pump and pump head and the KrosFlo II digital pressure monitor integrated into one compact unit.
KrosFlo Research IIi Pump 50/60 Hz
Forward/reverse digital motor control, 0.1-600 RPM
Attached U stand to support filter flow path, reservoirs and optional automatic backpressure valve.
KrosFlo Research Iii Pump Head with 3 Stainless Steel Rollers
Four orientations (left, right, up & down)
KrosFlo Digital Pressure Monitor
Digital LCD display with LED backlight
4 pressure measurements displayed
Inlet feed pressure
Retentate pressure
Permeate pressure
Transmembrane pressure (calculated)
KF Comm Data Collection Software
The KFComm Data Collection Software included with the system interfaces with a computer to download real time process operating information from the system to an Excel file. Information captured includes:
Inlet Feed pressure
Retentate pressure
Permeate pressure
Calculates and Trends:
Transmembrane pressure
Filtration Flux
Shear
Volumetric throughput
Water flux
Concentration Factor
The KrosFlo Research IIi "Octopus" Cable has multiple connections for all system components, including:
Connections for 3 pressure transducers (feed, retentate and permeate)
USB port for data capture on a computer
RS232 port to connect the optional Permeate Scale
RS232 port to connect the optional Back Pressure Valve
The Flow-path kit includes components needed to construct a flow path including:
Fittings for #13, 14, 16, 17 & 18 Tubing sizes
One each of 15mL, 50mL, 250mL 3 port conical bottom reservoirs
Packages of #14 and # 16 tubing
KrosFlo Filters are sold separately
The Starter Kit includes items needed to support the flow-path including
Reusable reservoir and filter holders
Flow restrictors
Bulb valve
Tie wraps
Tie Gun
21CFR Part 11 enabled when used with optional KF Comm Compliant Workbook and interface software package from OFNI (ExcelSafe™)
