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KrosFlo® LDF-37 System


Tangential Flow Filtration System for Pilot Scale Volumes

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The KrosFlo LDF-37 tangential flow filtration system is ideal for filtering Pilot Scale volumes ranging from 10L to 1000 L. The system consists of a digitally controlled 37LPM (9,77 GPM) capacity three roller peristaltic pump with jog-reverse and Spectrum's digital pressure monitor with 5 user defined alarms and automatic shut-off controls. The pump and the pressure monitor are housed on a mobile stainless steel cart with a hollow fiber filter stand and clamping brackets. The KrosFlo LDF-37 pump is UL and CE compliant and IP 56 rated. The LED keypad used for controlling recirculation rates has an integrated lock and unlock feature that prevents accidental or unauthorized changes. The mobile cart has an integrated computer workstation. Real-time processing data is collected and graphed by KF Comm data collection software. The system is designed for use with Spectrum Labs' Hollow Fiber filter modules or Single-Use filter module, bag and tubing sets (MBTs). MBTs are fully assembled and ready to use Single-Use flow-paths, which include hollow fiber filter modules, tubing, connectors, pressure sensors and processing totes or bags.

Used in conjunction with KrosFlo Single-Use Filters or Module Bags and Tubing Sets the LDF-37 offers the following advantages:

  • Uses fully assembled Single-Use flow paths
  • Lowers cost due to the elimination of cleaning and flow path assembly
  • Monitors pressure and flow rates for increased process control
  • Mobile to save space and maximize facility flexibility

System Components

LDF-37 digitally controlled peristaltic pump for use with B/T 87 or B/T 91 tubing

  • Flow Rates:
    • B/T 87 0,67-17,7 LPM/ 0,17-4,7 GPM
    • B/T 91 1,4-37LPM/ 0,4-9,8 GPM
  • 0,5 HP Motor with 320 RPM drive, 5 Amp
  • 1800 RPM NEMA 56C Face TENV, PMDC Motor with soft start electronic brake
  • Repeatability +/- 0,3%
  • Forward and Reverse Flow Control
  • Certifications: UL listed, CE marked and cUL (230V only)
  • Pump Head Material: Nylatron and Delrin rollers and polyester powder coated pump cover
  • IP 56 Wash down rating
  • Operating Temperature 0-400 C (32-1040 F)
  • Single Phase 115 VAC single phase USA standard plug or 230 VAC single phase European Plug

Microprocessor Controller

  • LED four digit display with 0,1 resolution in LPM with TTL pulse tachometer output

Manual Retentate Backpressure Valve

KrosFlo Digital Pressure Monitor

  • Displays 4 pressure measurements
    • Inlet feed pressure
    • Retentate pressure
    • Permeate Pressure
    • Transmembrane Pressure (calculated)
  • Allows operator to define high/low pressure alarm points and 2 automatic pump shut-off settings
  • UL listed and CE marked

KF Comm Data Collection Software

  • Automatically collects, records, calculates and graphs real time process data in a Microsoft® Excel® format
  • Records Inlet feed pressure, Retentate pressure and Permeate pressure
  • Calculates and Trends Transmembrane pressure, Filtration Flux, Shear, Volumetric throughput, Water flux and Concentration factor
  • 21CFR Part 11 enabled when used with optional KF Comm Compliant Workbook and interface software package from Ofni Systems (ExcelSafe)

RS232 Extension Cable for connection to PC

Digital Pressure Transducers

304 Stainless Steel Mobile Cart

  • Computer workstation with additional shelf for a secondary / permeate pump
  • 4 Clean room rated Casters-2 swivel locking, 2 fixed locking

Racking Unit/Clamps for KrosFlo or KrosFlo Max Filter Modules or KrosFlo MBTs

Optional Accessories

  • 3,4 LPM Digital Permeate Control Pump
  • KrosFlo Automatic Backpressure Valve for TMP or Permeate Pressure Control
  • Pro-Connex® Fittings Kit
  • Portable Totes and Processing Bags

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Advantages of Disposability

  • Easier FDA Validation
  • Saves Money & Time
  • No Cross-Contamination
  • Less Down-Time
  • Low Shear
  • Directly Scalable for Production
  • Easy Retrofit for other HF Modules

Filtration Resources:











System Applications:

  • Cell Harvesting/Clarification
  • Virus Purification
  • Cell Perfusion
  • VLP Purification
  • Lysate Clarification
  • Viral Clarification
  • Bacterial Concentration
  • Protein Purification
  • Micro-Particle Diafiltration
  • Antibody Purification
  • Macromolecular Isolation
  • Desalting and Buffer Exchange
  • NanoParticle Diafiltration

RELATED PRODUCTS:

Disposable KrosFlo MBT Sets
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KrosFlo Modules
for volumes from 10 - 100 liters
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Back Pressure Valve
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